Fallout 4 Best Weapons
Unlike previous installments, in Fallout 4, weapons fall under three classifications: Normal, legendary, and unique. Normal weapons have no special statistics on them whatsoever. Legendary weapons come with random bonuses applied to them, and are only dropped by legendary enemies.
Other Unique Weapons
There are several unique weapons in Fallout 4, weapons of which only one exists in the game world. Some are found in specific locations while others are obtained as quest rewards. These are different from legendary weapons which are randomly generated from a table of possible effects. Some unique weapons also have legendary effects without the normal legendary weapon prefix (eg. assassin's, hunter's, ghoul slayer's).
The Syringer is a weapon that uses air pressure to propel custom-made syringes at a target. Rather than dealing direct damage, the Syringer is used to weaken the target with various effects. This weapon supports a wide variety of injectable ammo, all of which can be crafted at chemistry stations.
Fat Man (Fallout 4)
According to terminals found inside the Fort Strong armory in Boston, the Fat Man was conceived, developed and tested at the location. Several houses have been constructed around the fort, to provide a testing area to ascertain how much damage the weapon would cause in an urban environment.
An unusual heavy weapon mixing 18th-century ordnance with 23rd-century technology. The main body consists of a small old-fashioned naval cannon (possibly a muzzle-loading swivel gun) strapped to a makeshift rig with metal rivets and thick ropes. This rig allows it to be carried around with both hands easily and includes a hinge allowing the cannon to be angled vertically for easy reloading. It fires explosive cannonballs via an electronic trigger taped to the back handle.
A pre-War semi-automatic handgun. It has an exposed hammer and a double-action trigger mechanism and the fixed barrel also acts as a guide rod for the recoil spring. It has a smaller size, shorter grip and reduced magazine capacity, in contrast with other pistols of the same chambering.
The Alien Blaster
The alien blaster is a weapon of great extremes. It has the highest damage-per-action-point of all single-shot weapons in both Fallout and Fallout 2, as well as the second-highest ammunition capacity of all single-shot weapons in both games. It is also highly accurate. Offsetting these strengths is its extremely short range of 10 hexes, the shortest of all ranged weapons in Fallout and the second-shortest in Fallout 2.